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The renal excretion of creatinine is regarded as relatively constant over the day in healthy individuals, allowing to calculate metabolite/creatinine ratios, typically presented as g metabolite per gram of creatinine (g/g creatinine) (Johner et al

Notably, in the condition of excess hemin exposure and hypoxia, our findings suggest an important contribution of the TSS pathway and its regulation by DMF for de novo cysteine synthesis and GSH generation in protecting against the oxidative and ferroptotic stresses in SCD erythroblasts

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